With the increasing adoption of stereoelectroencephalography (SEEG) for presurgical evaluation in drug-resistant epilepsy, clinicians face challenges in consistently formulating robust preimplantation hypotheses and accurately interpreting SEEG signals. These skills are critical for precise localization of the epileptogenic zone, yet variability in practice may limit surgical success. This session will address these gaps by reviewing best practices in hypothesis generation, highlighting key principles of anatomo-electro-clinical correlation, and providing practical strategies for systematic SEEG interpretation to optimize patient outcomes