Ask the Expert On-Demand Webinar: Real-World Experience and Tips for Treatment with Latest Antiseizure Medications-ATEWOD Real-World Experience and Tips for Treatment with Latest Antiseizure Medications

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Video Summary

In an informative webinar organized by the American Epilepsy Society (AES), experts discussed the latest anti-seizure medications, providing real-world experience and practical tips for treatment, essential for medical professionals dealing with epilepsy patients. Dr. David Vossler introduced medications like brivaracetam, cenobamate, and perampanel, focusing on their use in different seizure types, pharmacokinetics, mechanisms of action, and side effects. Brivaracetam was noted for its potency and limited side effects compared to levetiracetam, while cenobamate showed promise with significant seizure reduction and higher rates of seizure freedom among patients. Perampanel was highlighted for its effectiveness against primary generalized tonic-clonic seizures.<br /><br />Dr. Kevin Chapman discussed drugs targeting pediatric epileptic disorders, such as cannabidiol for Lennox-Gastaut and Dravet syndromes, and stiripentol and fenfluramine for Dravet syndrome. He addressed dosing strategies, pharmacokinetics, adverse effects, and considerations like drug interactions. Cannabidiol showed efficacy in reducing seizures with specific monitoring requirements for liver function. Stiripentol demonstrated high seizure-free rates, especially when used with clobazam, while fenfluramine required cardiac monitoring due to potential side effects.<br /><br />The webinar underscored the complexities and interactions of these medications, discussed their off-label uses, and emphasized the importance of patient-specific considerations, highlighting ongoing research avenues such as the use of ambulatory ECOG in epilepsy management. Overall, the session provided a comprehensive review of emerging treatments, equipping practitioners with knowledge to enhance epilepsy patient care.

Keywords

anti-seizure medications

epilepsy treatment

brivaracetam

cenobamate

perampanel

pediatric epilepsy

cannabidiol

stiripentol

fenfluramine

ambulatory ECOG